The Jalisco New Generation Cartel (CJNG) launched a coordinated assault on Mexico’s National Guard in San Isidro, Jalisco, on February 22, 2026, in retaliation for the military killing of cartel leader Nemesio “El Mencho” Oseguera Cervantes earlier that day. Dramatic video footage captured a CJNG convoy engaging in rapid vehicle maneuvers, with spent shell casings littering rural streets, indicative of a hit-and-run ambush that reportedly killed six National Guard members.

The attack forms part of a series of violent incidents across the state, claiming a total of 25 lives, with cartel operatives employing advanced weaponry and tactics to challenge government forces. Vehicle burnings, blockades, and widespread chaos ensued, prompting the U.S. embassy to issue alerts urging tourists to shelter in place.

Analysts note that CJNG’s operations demonstrate both strategic planning and operational sophistication, reflecting a broader trend of organized crime using high-intensity assaults against state security forces. Authorities continue to investigate the full scope of the attacks while bolstering security in vulnerable areas, aiming to restore order and prevent further escalation.